Endocrine Abstracts

IntroductionGraves orbitopathy is the main extra thyroidal manifestation of Graves’ disease, though severe forms are rare (< 5%). Management of Graves orbitopathy is often suboptimal, largely because available treatments do not target pathogenic mechanisms of the disease. The aim of our study was to evaluate different treatment modalities and assess their impact on the outcome of Graves orbitopathy.Patients and methods...

IntroductionPsychological disorders may be expected in patients with hyperprolactinemia. Indeed, they generally have poor quality of life, anxiety, depression and certain personality troubles. Dopamine agonists are the first-line treatment of prolactinoma. Recently, an increasing number of reports emphasized on dopamine agonists psychological side effects. Effectively, some patients develop de novo psychiatric symptoms or have exacerbation of pre-existin...

Gender is a factor in clinical presentation, biological and morphological characteristics in certain types of pituitary adenomas. Concerning acromegaly, this influence is not well known. In our retrospective study of 32 patients, 12 women and 20 men, hospitalized in our department from 2002 to 2019, we have realized a comparative clinical, para-clinical, therapeutic and prognosis. The median age of women is 47 years, the same as that of men. The average duration of disease pro...

IntroductionAcromegaly is a rare chronic disorder caused by GH hypersecretion. It’s associated with an elevated morbidity and mortality rate. Cardiovascular diseases’ complications are the first cause of mortality in patients. In this study we conducted an assessement of cardivascular risk factors in patients with acromegaly.Patients and methodsA retrospective evaluative study of 32 patients followe...

Patients with polycystic ovary syndrome (PCOS) have features of the metabolic syndrome, including insulin resistance, obesity, and dyslipidemia, suggesting an increased risk for cardiovascular disease.ObjectiveTo assess the prevalence of metabolic syndrome in patients with a polycystic ovarian sydrome (PCOS).MaterialWe conducted a retrospective study including 51 patients with secondary...

IntroductionThyroid hemiagenesis is defined as the absence of one lobe of the thyroid gland. It represents a rare congenital abnormality with a prevalence of 0.05 to 0.2%. The left lobe is more commonly affected than the right lobe. Thyroid hemiagenesis is incidentally found during a routine thyroid screen. Herein, we report a thyroid hemiagenesis revealed by a compensatory hypertrophy of the contralateral thyroid lobe in an adolescent girl with euthyroi...

IntroductionGraves’ disease is typically characterized by the presence of circulating autoantibodies that stimulate the TSH receptor, inducing hyperthyroidism and goiter. Hashimoto’s thyroiditis is an autoimmune disease leading to thyroid tissue destruction by cell and antibody-mediated immune processes. The development of Hashimoto’s thyroiditis following Graves’ disease is rarely reported. Its pathogenesis is not confirmed. Herein, ...

Introduction: Cardiovascular diseases are frequent in patients with hypopituitarism receiving conventional hormone replacement therapy. They represent the main cause of premature death in this population. Emerging evidence smggests that beyond traditional risk factors, evaluating coronary calcium score (CCS) and inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) provides valuable insights into cardiovascular health in this population. The aims of the pre...

Introduction: Insulin resistance is classically a feature of type 2 diabetes mellitus (T2D). It may also develop among patients with type 1 diabetes (T1D) increasing the risk of cardiovascular mortality. Metabolic syndrome (MS) reflects a state of IR. The aim of this study was to assess the frequency of MS in a population of young adults with T1D and compare it to healthy controls.Methods: We conducted a case control study including 68 T1D patients and 6...

Introduction: Patients with Sheehan’s syndrome (SS) may experience alterations in blood pressure (BP) regulation, possibly due to hormones deficiencies and hormone replacement treatment. The aim of the present study was to assess the 24h ambulatory BP in women with Sheehan syndrome.Methods: This was a monocentric cross-sectional study involving 50 women with complete anterior hypopituitarism secondary to SS and 50 age and body-mass index (BMI) match...